Bibliometric analysis of exosomes in skin aging: Key trends and hotspots (2015-2024).

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Exosomes, as nanosized extracellular vesicles, play a crucial role in regulating cellular communication and mediating biological processes related to skin aging, including oxidative stress, inflammation, and extracellular matrix homeostasis. This study aims to provide a comprehensive overview of the current status, key trends, and hotspots in exosome research focused on skin aging. Bibliometric analysis was performed using CiteSpace (Version 6.4.R1), VOSviewer (Version 1.6.20), and Excel (v2021). Data were collected from the Science Citation Index Expanded of Web of Science Core Collection, covering publications from 2015 to 2024. Analyses included publication trends, country/region distribution, institutional contributions, key journals, influential authors, citation patterns, exosome sources, and research hotspots. A total of 165 relevant publications (114 original articles and 51 reviews) were identified, with a significant upward trend in publications since 2020, peaking in 2024. China contributed the largest number of publications (84), followed by South Korea (28) and the USA (20). Shanghai Jiao Tong University (China) was the most productive institution, while International Journal of Molecular Sciences published the highest number of articles in this field. BEHFAR A, GAO W, and PARK JH were the most productive authors, and Shabbir A's 2015 article in Stem Cells and Deve

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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