Bidirectional regulation factor of bone marrow mesenchymal stromal cells differentiation: a focus on bone-fat balance in osteoporosis.
Xiong Z., Song Y., Wu J., Lu W., Xiong J., Zhu M.
Narrative Review, published in Stem Cell Res Ther (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Stem Cell Res Ther (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41331786
- DOI
- 10.1186/s13287-025-04838-w
Abstract (original English)
Bone marrow mesenchymal stromal cells (BMSCs) are multipotent progenitors that can differentiate into osteoblasts or adipocytes. A dynamic equilibrium exists between osteogenesis and adipogenesis, referred to as the bone-fat balance. Under pathological conditions, BMSCs often display reduced osteogenic potential and enhanced adipogenic differentiation, resulting in a disrupted bone-fat balance that contributes to the development and progression of bone disorders such as Osteoporosis. Understanding the factors that bidirectionally regulate this balance is essential for identifying novel therapeutic targets for Osteoporosis. This review summarizes the regulatory mechanisms that can modulate osteogenic and adipogenic differentiation in both directions. The identified regulators are systematically categorized into four main groups according to their molecular characteristics: proteins, chemical compounds, non-coding RNAs (ncRNAs), and physical factors. Each regulatory factor employs distinct molecular strategies to influence the balance between bone and fat. This framework provides an integrated understanding of BMSCs fate determination and highlights possible therapeutic approaches targeting the bidirectional regulators of osteogenic and adipogenic differentiation.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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