Biodegradable Metal-Based Stents: Advances, Challenges, and Prospects
Sun L., Zeng Y., Shen Z., Yue C., Yang Y., Gao J.
Narrative Review, published in J Funct Biomater (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- J Funct Biomater (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41003386
- PMCID
- PMC12470573
- DOI
- 10.3390/jfb16090315
- Citations
- 1
Abstract (original English)
Cardiovascular disease is a leading cause of global mortality. Percutaneous coronary intervention, which involves the placement of stents to restore blood flow in narrowed arteries, is a widely used treatment. However, traditional stents, such as bare metal stents and drug-eluting stents, can lead to long-term complications such as restenosis, inflammation, and thrombosis. Biodegradable metallic vascular stents, with their superior mechanical properties, excellent biocompatibility, and gradual degradation in vivo, hold significant potential for the treatment of coronary artery disease. This review provides a comprehensive overview of the current research status and challenges. Firstly, it outlines the design principles and performance evaluation methods for biodegradable stents, which focus on mechanical properties, chemical characteristics, corrosion behavior, and biocompatibility. Furthermore, it summarizes the material features, degradation mechanisms, and metabolic behavior of three primary biodegradable metals-magnesium alloys, iron alloys, and zinc alloys-and discusses critical issues such as the degradation rate of different alloys and the development of zinc alloys. Finally, based on the current achievements and challenges of studies on biodegradable metal-based stents, this article proposes some optimization strategies and research prospects.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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