Level D· Scientific groundwork from lab and animal studiesLaboratory StudyEurope PMCOpen access

Biologically Enhanced Repair of Interstitial Rotator Cuff Tears With Intralesional Platelet-Rich Plasma and Bursal Tissue Injection

Richards DP., George TM.

Laboratory Study on Tendon Injury, Rotator Cuff, Shoulder Pain, published in Arthrosc Tech (2025) — summary generated from the PubMed abstract.

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Level D· Scientific groundwork from lab and animal studiesEvidence level of this study

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
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This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Laboratory Study
Journal
Arthrosc Tech (2025)
Reported sample size
—
Source database
Europe PMC
PMID
40656754
PMCID
PMC12255449
DOI
10.1016/j.eats.2025.103470

Abstract (original English)

Rotator cuff tendinopathy is a common and important source of shoulder pain. Symptoms tend to worsen over time and can progress to partial- or full-thickness rotator cuff tears. This can lead to increased pain and a further decrease in function. The use of orthobiologics for surgical augmentation has been a subject of much interest and discussion regarding its potential adjuvant assistance in rotator cuff reconstruction. We describe a transtendinous repair of large interstitial rotator cuff tears augmented by injecting platelet-rich plasma and autologous bursal tissue into the interstitial defect prior to reconstruction.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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