Biomaterial-mediated Cell Atlas: an insight from single-cell and spatial transcriptomics
Yang X., Huang M., Chen H., Dai J., Chen J., Chen K.
Narrative Review, published in Bioact Mater (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Bioact Mater (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40821937
- PMCID
- PMC12356410
- DOI
- 10.1016/j.bioactmat.2025.07.047
- Citations
- 6
Abstract (original English)
Biomaterials serve as bridges between synthetic structures and biological systems, facilitating interactions with bodily tissues and regulating cellular responses. However, the intricate mechanisms governing cell-material interactions within the body are not fully understood. To address these challenges, single-cell transcriptomics and spatial technologies have emerged as promising tools. This review introduces the concept of the 'Biomaterial-mediated Cell Atlas' and summarizes its recent advances in biomaterials research. Building upon the framework of the Human Cell Atlas, it can extend its scope to include biomaterial-mediated cellular responses. The principles and workflows of single-cell and spatial transcriptomics are then presented, emphasizing their potential to reveal cellular diversity and spatial arrangements affecting material-cell interactions. Furthermore, transcriptomics-driven approaches are highlighted for their potential in mapping biomaterial-cell communication pathways, which are essential for elucidating biological mechanisms and guiding material design. Challenges inherent to current methodologies and emerging frontiers in this interdisciplinary field are discussed.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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