BMP-9 induces rabbit adipose-derived stem cells to differentiation into osteoblasts via BMP signaling pathway.
Chai Y., Liu F., Li Q., Shen Y., Ding WY.
Animal Study, published in Anal Quant Cytopathol Histpathol (2013) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Anal Quant Cytopathol Histpathol (2013)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 24344505
- Citations
- 3
Abstract (original English)
Objective To explore the role of BMP-9 in osteoblast differentiation from adipose-derived stem cells (ADSCs). Study design Rabbit ADSCs were isolated from subcutaneous tissues of the abdomen and inguinal fat pads and then purified and expanded in vitro. AdBMP9, SB203580 (P38 MAPK inhibitors), and PD98059 (ERK1/2 inhibitor) were used for osteoblastic differentiation. Results The results show that bone morphogenetic proteins (BMPs) could affect the differential direction of ADSCs. Polymerase chain reaction assays reveal the important role of BMP signaling pathway in osteoblastic differentiation of ADSCs, and the members included Smad 1, Smad 4, Smad 5, Smad 8, P38, ERK1/2, Runx 2, collagen type I and osteopontin. Conclusion This study provides some theoretical basis and experimental evidence for the application of ADSCs into treatment of bone injury.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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