Bone equilibria and disruptions.
van Bosse HJP.
Laboratory Study, published in J Pediatr Soc North Am (2024) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- J Pediatr Soc North Am (2024)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40433272
- DOI
- 10.1016/j.jposna.2024.100059
Abstract (original English)
Osteoporosis is considered a disease of adulthood, but there is increasing recognition that poor bone density during childhood can have effects decades later. To understand the pathogenesis of osteoporosis, it is important to understand normal bone maintenance and remodeling, since disruptions of these processes lead to pathologic bone. Bone maintenance is a complex and highly regulated system, consisting of several homeostatic equilibria. This article highlights three homeostatic systems. The first, the interplay between the differentiation of osteoblasts from mesenchymal stem cells and osteoclasts from hematopoietic stem cells, is the most important. Estrogen has a direct effect on the system, and its absence is pivotal. The second is a lesser-known homeostasis that functions between bone and bone marrow adipose tissue, which can insidiously drive osteoporosis. Bone marrow adipose tissue acts as a regulator of bone metabolism, negatively affecting bone formation. The third homeostatic system covered is the microbiota-gut-bone axis, where the make-up of the gut microbiome can influence a balance between osteoblastic and osteoclastic T-cells. Understanding these systems has provided avenues of study for existing and future treatments. (1)The balance between bone formation and bone resorption is driven by factors that initiate the differentiation of mesenchymal stem cells to ost
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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