Bone marrow-derived and adipose-derived stem cells on bacterial nanocellulose-chitosan-gelatin-hydroxyapatite scaffolds for bone tissue engineering.
Phatchayawat PP., Yodmuang S., Phisalaphong M.
Animal Study, published in J Biomater Sci Polym Ed (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- J Biomater Sci Polym Ed (2026)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 42296470
- DOI
- 10.1080/09205063.2026.2685391
Abstract (original English)
Bone marrow-derived MSCs (BM-MSCs) and adipose-derived MSCs (AD-MSCs) are both multipotent with therapeutic potential. In this study, a study for bone tissue engineering was performed using both cell types on three-dimensional (3D) bacterial nanocellulose-chitosan-gelatin-hydroxyapatite (BNC-CS-GT-HAp) scaffolds compared to other bacterial nanocellulose-based scaffolds. BM-MSCs and AD-MSCs show superior potential for osteogenic differentiation, mineralization and extracellular matrix formation on BNC-CS-GT-HAp scaffolds. However, compared with AD-MSCs, BM-MSCs demonstrate greater cell proliferation and osteogenic differentiation, evidenced by higher alkaline phosphatase (ALP) activity, mineral deposition and osteogenic gene expression over 28 days of cultivation. Further investigation of BM-MSCs for a long-term cultivation of 56 days showed extensive bone matrix formation, persistent ECM and mineral deposition, and enhanced scaffold mechanical reinforcement. Under the cultivation of BM-MSCs on BNC-CS-GT-HAp for 56 days, the production of collagen increased to 4.89%wt/wt and the compressive strength increased to 283 MPa. This indicates the potential of BM-MSCs for osteogenic differentiation and bone regeneration, even after extended periods in vitro . The results demonstrate the potential of BNC-CS-GT-HAp scaffolds as a promising candidate for in vivo bone regeneration applicati
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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