Bone Morphogenetic Proteins in Orthopedics: A Bibliometric Analysis

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Objective Bone morphogenetic proteins (BMPs), with their osteoinductive properties, present a potential alternative, but their safety and efficacy are still debated. This study seeks to understand BMPs research in orthopedics through bibliometric analysis, assessing the current state and identifying research trends and frontiers. Methods A literature search was conducted in the Web of Science Core Collection database for English-language articles pertaining to BMPs and orthopedic themes from January 1, 1900, to November 1, 2024. Bibliometric parameter extraction, CiteSpace, Microsoft Excel were employed for data processing and network visualization analysis. Results This study included a total of 1048 articles, demonstrating sustained research activity in BMPs applications in orthopedics over the past 32 years. In this domain, Takaoka Kunio was identified as the most prolific author. The United States was the most productive country, with the University of California System emerging as the leading institution. The Journal of Orthopaedic Research and Science were recognized as the most productive and frequently cited journals, respectively. Keyword analysis highlighted research hotspots, including the application of BMPs in spinal fusion surgery, bone tissue engineering, and gene therapy. Studies concerning BMP-induced differentiation of mesenchymal stem cells (MSCs) and the dev

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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