Breast Cancer-Associated Adipose Tissue Histologic Subtypes: Microscopic Characterization and Their Impact on Prognosis and Survival, Depending on Age.
Pasca Fenesan MM., Bogdan RG., Cosma AA., Vornicu V., Melnic E., Radu DV.
Prospective Study, published in Cancers (Basel) (2026) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Cancers (Basel) (2026)
- Country
- Switzerland
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41899569
- PMCID
- PMC13024802
- DOI
- 10.3390/cancers18060966
- Citations
- 1
Abstract (original English)
Background/Objectives : The fundamental classification based on white, brown, pink, and beige adipose tissue morphology together with fat vacuole content released into the tumor microenvironment incompletely defines breast cancer-associated adipose tissue (BCAAT) heterogeneity and does not sufficiently explain its controversial impact on invasion, recurrence, or survival in breast cancer (BC). We aim to expand BCAAT characterization by systematically evaluating stromal cellular elements within peritumoral adipose tissue, including CD34-positive fibroblasts, smooth muscle actin (SMA)-positive myofibroblasts, inflammatory cells, and microvascular structures to define distinct BCAAT subgroups. Methods : CD34 and smooth muscle actin (SMA) double immunohistochemistry was performed on 109 BC tissue specimens from patients aged 35 to 79 years old, followed by microscopic evaluation of cellular and vascular components inside peritumor adipose tissue. Microscopic findings were then correlated to age, body mass index (BMI), lymphovascular (LVI) and perineural invasion (PnI), recurrence (R), and tertiary lymphoid structures (TLSs). Results : Four BCAAT subtypes have been identified as fibroblast-rich (F Rich _BCAAT), myofibroblast-rich (MyoF Rich _BCAAT), vascular-rich (V Rich _BCAAT), and mixed-vascular and inflammatory-rich (VI Rich _BCAAT). The F Rich _BCAAT subtype predominates for th
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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