Candidate Scaffolds for the Treatment of Stress Urinary Incontinence: A Narrative Review.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Aims Biodegradable scaffolds have emerged as a promising alternative to polypropylene (PP) meshes for the treatment of stress urinary incontinence (SUI) due to their biocompatibility and potential for tissue regeneration. Methods A narrative review was conducted focusing on articles published within the last 10 years. Results Polymeric materials such as small intestinal submucosa (SIS), poly(lactic acid) (PLA), poly(Chitosan-g-lactic Acid) (PCLA), poly(glycolic acid) (PGA), and poly(lactic-co-glycolic acid) (PLGA) have been explored for their ability to provide mechanical support, facilitate tissue repair, and degrade in a controlled manner. Each material offers unique advantages, such as SIS's enhanced biocompatibility, PLA's mechanical strength, and PGA's rapid degradation. However, challenges remain in optimizing these materials for clinical use, including controlling degradation rates, minimizing inflammatory responses, and addressing issues related to scaffolds' mechanical properties. Moreover, integrating adipose-derived stem cells (ADSCs) has shown promise in enhancing tissue regeneration and angiogenesis. The primary obstacles preventing clinical implementation have been premature scaffold degradation before adequate tissue ingrowth and insufficient tensile strength in dynamic pelvic environments. Conclusions This review discusses the current state of biodegradable scaf

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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