Cannula Size Effect on Stromal Vascular Fraction Content of Fat Grafts.
Becker H., Vazquez OA., Rosen T.
Prospective Study with a reported sample of 10, published in Plast Reconstr Surg Glob Open (2021) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Plast Reconstr Surg Glob Open (2021)
- Country
- United States
- Reported sample size
- 10
- Source database
- PubMed
- PMID
- 33907655
- PMCID
- PMC8062151
- DOI
- 10.1097/GOX.0000000000003471
- Citations
- 3
Abstract (original English)
Background Fat is an active and dynamic tissue composed of adipocytes supported by a structural framework known as the stromal vascular fraction (SVF). SVF is traditionally isolated by enzymatic processing, but new methods are being investigated to isolate it mechanically. Recent studies propose that fat harvested with larger cannulas has a higher survival rate, most likely due to a higher concentration of SVF. Methods Lipoaspirates were obtained from 10 patients who underwent elective liposuction using a 5-mm and a 1-mm cannula attached to a syringe using standard pressure. The fat was aspirated from the same area at adjacent sites. An estimated 5-mm fat particles were also cut down to 1-mm using a micronizer (Marina Medical). A 5-cm 3 volume of each sample was compressed through a 0.5-mm opening strainer and rinsed with normal saline to extrude the oil. The resultant SVF left on the strainer was then measured in a 1-cm 3 syringe. Results The volume extracted from a 5-mm cannula (mean, 0.23 cm 3 ; SD, 0.10) versus a 1-mm cannula (mean, 0.11 cm 3 ; SD, 0.06) was statistically significant ( P = 0.009). An H&E-stained slide from the SVF was obtained for confirmation. Finally, 5-mm fat particles cut down to 1-mm particles using the micronizer resulted in an average volume of 0.20 cm 3 , which was higher than the average volume harvested with a 1-mm cannula. Conclusions Harvesting
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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