Case Report of a patient with Madelung's disease combined with alcoholic liver disease and liver cirrhosis
Gu Z., Hao Y., Duan J., Zhao K.
Case Report / Series on Systemic / IV, published in Front Med (Lausanne) (2025) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Case Report / Series
- Journal
- Front Med (Lausanne) (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41347003
- PMCID
- PMC12673482
- DOI
- 10.3389/fmed.20251695921
Abstract (original English)
Background Madelung's disease (MD) is a rare disorder of fat metabolism, with symptoms often characterized by the appearance of chronic accumulations of abnormal adipose tissue in areas such as the neck and neckline, upper back and chest. Nowadays, its pathogenesis is still unknown, and some scholars have suggested that its etiology is closely related to alcohol consumption, and that it is associated with a variety of metabolic diseases such as liver disease, hypertension, diabetes mellitus, dyslipidemia, and peripheral neurological damage. Currently, there are very few reported cases of Madelung's disease complicated by alcoholic liver disease and liver cirrhosis (LC), making this case worthy of reporting. Case summaries This article reports on a 60-year-old man, the main point of view "The patient has experienced edema in both lower limbs for 2 weeks, accompanied by a long history of alcohol consumption." Clinical examination showed subcutaneous swelling of the neck, which has been clearly present for three years. The diagnosis of Madelung's disease combined with alcoholic liver disease and liver cirrhosis was made based on laboratory tests of liver function, ultrasound of the neck vessels, ultrasound of the superficial tissues of the neck, and CT of the abdomen. The patient has not exhibited restricted neck mobility or symptoms of tracheoesophageal fat syndrome, which affect
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • Without an adequate control group, treatment effects cannot be separated from other factors.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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