Causal associations between both psoriasis and psoriatic arthritis and multiple autoimmune diseases: a bidirectional two-sample Mendelian randomization study

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Numerous observational studies have identified associations between both psoriasis (PsO) and psoriatic arthritis (PsA), and autoimmune diseases (AIDs); however, the causality of these associations remains undetermined. Methods We conducted a bidirectional two-sample Mendelian Randomization study to identify causal associations and directions between both PsO and PsA and AIDs, such as systemic lupus erythematosus (SLE), Crohn's disease (CD), ulcerative colitis (UC), multiple sclerosis (MS), uveitis, bullous pemphigoid (BP), Hashimoto's thyroiditis (HT), rheumatoid arthritis (RA), vitiligo, and ankylosing spondylitis (AS). The causal inferences were drawn by integrating results from four regression models: Inverse Variance Weighting (IVW), MR-Egger, Weighted Median, and Maximum Likelihood. Furthermore, we performed sensitivity analyses to confirm the reliability of our findings. Results The results showed that CD [IVW odds ratio (OR IVW ), 1.11; 95% confidence interval (CI), 1.06-1.17; P = 8.40E-06], vitiligo (OR IVW , 1.16; 95% CI, 1.05-1.28; P = 2.45E-03) were risk factors for PsO, while BP may reduce the incidence of PsO (OR IVW , 0.91; 95% CI, 0.87-0.96; P = 1.26E-04). CD (OR IVW , 1.07; 95% CI, 1.02-1.12; P = 0.01), HT (OR IVW , 1.23; 95% CI, 1.08-1.40; P = 1.43E-03), RA (OR IVW , 1.11; 95% CI, 1.02-1.21, P = 2.05E-02), AS (OR IVW , 2.18; 95% CI, 1.46-3.27; P = 1.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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