Characterization of Eco-Friendly Fabricated and Induction-Sintered Hydroxyapatite-Based Hybrid Composites
Usta EN., Demirkol N., Turan BC., Gürbüz M., Göller G., Barbaro K.
Laboratory Study, published in Materials (Basel) (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Materials (Basel) (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41374201
- PMCID
- PMC12692899
- DOI
- 10.3390/ma18235359
Abstract (original English)
In this study, eco-friendly sheep hydroxyapatite (KHO) powder was produced from sheep femur bone waste. Hybrid composite powders were prepared by adding varying amounts of MgO and MgO-graphene to the produced sheep hydroxyapatite powders and sintering them at 1200 °C for 5 min using induction sintering. The physical, mechanical, microstructural, in vitro bioactivity, cell culture, and antibacterial properties were studied. According to the results of the study, the density and compressive strength values of the samples containing 1 wt.% MgO and 1 wt.% MgO-0.1 graphene (KHM1 and KHM1GRF0.1), which had the best density and compressive strength values, were determined to be 2.771 g/cm 3 -28.42 MPa and 2.636 g/cm 3 -26.25 MPa, respectively. According to the in vitro bioactivity test in simulated body fluid, these composites exhibited bioactivity, with a dense hydroxy carbona apatite layer forming. Moreover, according to the cell culture and antibacterial test results, it was determined that sheep-derived hydroxyapatite, resulting from induction sintering with MgO and graphene, exhibited excellent biocompatibility, enhanced osteogenic potential, and moderate antimicrobial activity. In summary, these sheep hydroxyapatite hybrid composites exhibited higher mechanical strength and excellent integrated biological performance, confirming their substantial potential as advanced biomateria
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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