Characterization and lineage tracing of a mouse adipose depot reveal properties conserved with human supraclavicular brown adipose tissue
Li L., Feldman BJ.
Animal Study, published in Stem Cell Reports (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Stem Cell Reports (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40409261
- PMCID
- PMC12181967
- DOI
- 10.1016/j.stemcr.2025.102509
- Citations
- 2
Abstract (original English)
Enhancing energy utilization by increasing the number or activity of beige adipocytes has the potential to be of therapeutic benefit for a broad range of metabolic disorders. However, knowledge gaps in our understanding of the mouse versus human developmental origins of beige fat have inhibited the generation of robust preclinical models, leaving a barrier to the success of therapies. Here, we report that a distinct inguinal beige adipose tissue (ibAT) depot lineage traces to the same Prx1+ cell origins as inguinal white adipose tissue (iWAT) but maintains higher thermogenic activity and capability during aging. We discovered that ibAT has the morphological appearance of human supraclavicular brown adipose tissue (scBAT) and, importantly, conserved molecular markers and developmental origins with human scBAT. Our findings reveal a distinct mouse beige adipose tissue depot and provide a preclinical model of human beige adipose tissue development and maintenance.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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