Level D· Preclinical EvidenceAnimal Study

Characterization and therapeutic application of canine adipose mesenchymal stem cells to treat elbow osteoarthritis.

Kriston-Pál É., Czibula Á., Gyuris Z., Balka G., Seregi A., Sükösd F.

Animal Study on Osteoarthritis, published in Can J Vet Res (2017) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type: Animal Study
Journal: Can J Vet Res (2017)
Country: Canada
Reported sample size: —
PMID: 28197017

Abstract (original English)

Visceral adipose tissue (AT) obtained from surgical waste during routine ovariectomies was used as a source for isolating canine mesenchymal stem cells (MSCs). As determined by cytofluorimetry, passage 2 cells expressed MSC markers CD44 and CD90 and were negative for lineage-specific markers CD34 and CD45. The cells differentiated toward osteogenic, adipogenic, and chondrogenic directions. With therapeutic aims, 30 dogs (39 joints) suffering from elbow dysplasia (ED) and osteoarthritis (OA) were intra-articularly transplanted with allogeneic MSCs suspended in 0.5% hyaluronic acid (HA). A highly significant improvement was achieved without any medication as demonstrated by the degree of lameness during the follow-up period of 1 y. Control arthroscopy of 1 transplanted dog indicated that the cartilage had regenerated. Histological analysis of the cartilage biopsy confirmed that the regenerated cartilage was of hyaline type. These results demonstrate that transplantation of allogeneic adipose tissue-derived mesenchymal stem cells (AT-MSCs) is a novel, noninvasive, and highly effective therapeutic tool in treating canine elbow dysplasia. Du tissu adipeux viscéral (TA) obtenu de résidus chirurgicaux lors d’ovariectomies de routine a été utilisé comme source pour isoler des cellules souches mésenchymateuses canines (CSMs). Tel que déterminé par cytofluorométrie, les cellules du 2 e p

What this study does not prove

• This study does not prove SVF is an approved treatment or a replacement for standard care.
• This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence comes from animal or laboratory studies and has not been confirmed in humans.

How we grade evidence

AnimalsDog DiseasesDogsForelimbIntra-Abdominal FatJointsMesenchymal Stem Cell TransplantationOsteoarthritis

Arm & Elbow Osteoarthritis

View on PubMed

Characterization and therapeutic application of canine adipose mesenchymal stem cells to treat elbow osteoarthritis.

Abstract (original English)

What this study does not prove

Evidence level

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