Chemerin as a Mediator of Hypertension and Cardiometabolic Diseases (A Comprehensive Review)

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Purpose Chemerin, a recently identified adipokine, has emerged as a critical mediator in multiple physiological systems with significant implications for human health and disease. This review synthesizes current knowledge on chemerin's multifaceted roles across cardiovascular, renal, immune, and metabolic processes. Acting through its primary receptor CMKLR1, chemerin influences sympathetic nervous system activity in key brain regions including the nucleus tractus solitarius and paraventricular nucleus, thereby regulating blood pressure and cardiovascular function. Recent findings In the kidneys, elevated chemerin levels correlate with declining renal function, serving as both a biomarker and pathogenic factor in chronic kidney disease progression and diabetic nephropathy. As an immune modulator, chemerin facilitates leukocyte recruitment, promotes macrophage polarization toward pro-inflammatory phenotypes, and enhances endothelial inflammation, establishing it as a pivotal link between metabolic dysregulation and chronic inflammatory states. Chemerin plays a central role in hypertension by altering endothelial function, renal function and sympathetic outflow. In metabolic regulation, chemerin influences adipocyte differentiation, glucose homeostasis, and central appetite control, connecting obesity with systemic inflammation and insulin resistance. The convergence of these div

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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