Chicken intramuscular preadipocyte-derived exosome miR125b-5p promotes lipogenic differentiation of skeletal muscle satellite cells
Du J., Kong L., Cui J., Jiang W., Ma T., Yang Q.
Animal Study, published in Poult Sci (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Poult Sci (2026)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41846076
- PMCID
- PMC13010931
- DOI
- 10.1016/j.psj.2026.106753
Abstract (original English)
Intramuscular fat (IMF) content critically determines chicken meat quality. Extracellular vesicles (EVs) are essential mediators of intercellular communication through bioactive molecule transfer. Although co-culture systems have demonstrated that intramuscular preadipocytes (IMPs) promote lipogenic differentiation of muscle satellite cells (MSCs), the involvement of EVs remained unclear. Here, we isolated IMP-derived exosomes and confirmed their ability to enhance lipid accumulation in MSCs. Through small RNA sequencing and functional validation, we identified miR-125b-5p as a key regulator that directly targets and suppresses NR5A2, a newly identified negative regulator of avian adipogenesis. Inhibition experiments confirmed the essential role of this axis, as miR-125b-5p inhibition attenuated exosomal pro-adipogenic effects. Collectively, we demonstrated that IMP-derived exosomes facilitate MSC lipogenic differentiation through miR-125b-5p delivery. Our findings provide the first evidence of exosome-mediated muscle-fat crosstalk in poultry, establishing the miR-125b-5p/NR5A2 axis as a potential target for IMF modulation.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
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