Chlorogenic acid inhibits intestinal lipid uptake and promotes adipose lipid catabolism via epithelium-derived exosomes in ob/ob mice.
Yan Y., Zhou Y., Wang D., Zhou X.
Laboratory Study, published in Front Physiol (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Front Physiol (2026)
- Country
- Switzerland
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 42591088
- DOI
- 10.3389/fphys.2026.1896020
Abstract (original English)
Chlorogenic acid has been widely reported to regulate lipid metabolism and alleviate obesity; however, its effects on intestinal lipid uptake and adipose tissue catabolism, as well as the underlying mechanisms, remain incompletely understood. In the present study, diabetic ob/ob mice were treated with chlorogenic acid, which significantly improved metabolic parameters, including body weight, serum triglyceride levels, glucose tolerance, and insulin sensitivity. Notably, chlorogenic acid reduced intestinal lipid content and downregulated the expression of genes involved in lipid transportation. Concurrently, epididymal adipose tissue weight was decreased, accompanied by enhanced expression of genes associated with lipid catabolism. Mechanistically, chlorogenic acid decreased triglyceride level and suppressed PPARγ protein expression in IPEC-J2 cells. Activation of PPARγ attenuated the inhibitory effects of chlorogenic acid on lipid accumulation, indicating a critical role of PPARγ signaling. In addition, chlorogenic acid altered the concentration of epithelial cell-derived exosomes. These exosomes reduced triglyceride levels and modulated the expression of lipid metabolism-related genes in 3T3-L1 cells. Collectively, our findings suggest that chlorogenic acid may exert metabolic benefits, at least in part, through a coordinated intestine-adipose axis and provide preliminary evid
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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