Chronic inflammation induced by microneedling and the use of bone marrow stem cell cytokines.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Physicians advocating the frequent use of microneedling for skin care are advocating for a potentially dangerous procedure, especially when coupled with the topical application of bone marrow stem cell derived cytokines. Not only are the physicians who advocate for frequent microneedling as a skin care procedure not Board Certified in Dermatology (FAAD or FAOCD), they are not dermatologist; rather they are family practitioners. Further, they don't have M.D. or D.O. medical doctorate degrees, rather they have truncated bachelor in medicine degrees with limited education and training. Unlike board certified dermatologists, these physicians simply have neither a deep knowledge of dermatology, nor knowledge of the immunology of the skin. These physicians have developed and promulgated books, blogs, and training classes for these procedures that are offered to non-physicians, often to estheticians. Advocating the frequent use of microneedling for skin care, especially when coupled with the topical application of bone marrow stem cell derived cytokines induces a damaging chronic inflammatory state in the skin, and likely systemic inflammation too. Microneedling of the skin, even under sterile conditions, elicits a sterile inflammatory response, including early recruitment of neutrophils, throughout the layers of the skin, and even systemically. Given the non-sterile nature of the ski

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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