Circadian rhythm disruption as a potential contributor to BPPV: Evidence from a young rat model vestibular effects of circadian disruption
Otlu HG., Korkmaz H., Bulut ND., Göktürk N.
Animal Study, published in PLoS One (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- PLoS One (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 41468411
- PMCID
- PMC12752956
- DOI
- 10.1371/journal.pone.0339869
Abstract (original English)
Circadian rhythm disturbances, increasingly common due to artificial lighting and modern lifestyle factors, may underlie vestibular dysfunction such as benign paroxysmal positional vertigo (BPPV), even in younger populations. This study aimed to investigate the effects of circadian rhythm disruption on balance performance and vestibular biomarkers in a young rat model. Young male Wistar rats were exposed to constant light (CL) for 4 weeks to induce circadian disruption, while control rats were maintained under a standard 12:12-hour light-dark cycle. Following the exposure, serum and cochlear tissues were analyzed for otolin-1, vitamin D3, melatonin, and electrolytes (Ca² ⁺ , Na ⁺ , K ⁺ , Cl⁻). Balance was evaluated using the rotarod performance test. Constant light exposed rats showed significantly elevated otolin-1 levels in both serum and cochlear tissues, along with reduced melatonin levels and impaired rotarod performance. Vitamin D3 levels were lower in the CL group, while serum electrolytes remained unchanged. Circadian rhythm disruption may impair vestibular function in young rats via melatonin related pathways or otolin-1 modulation, independent of serum electrolytes. Our results imply that circadian rhythm disruption may contribute to BPPV through pathways unrelated to aging or bone metabolism.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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