Cold adaptation modulates Ca2+ signaling in brown preadipocytes.
Baumuratov AS., Abzhalelov BB., Kramarova LI., Dolgacheva LP., Zinchenko VP., Bronnikov GE.
Animal Study, published in Bull Exp Biol Med (2004) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Bull Exp Biol Med (2004)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 15514722
- DOI
- 10.1023/b:bebm.0000046937.88720.89
Abstract (original English)
One-week cold exposure of mice led to a 2-fold increase in the density of alpha1-adrenoceptors in brown adipose tissue. The density of alpha1-adrenoceptors returned to normal after adaptation to cold for 2 weeks. The reduced Ca2+ signaling in stem cells of brown fat activated via beta-adrenoceptors and cAMP was transformed into the Ca2+-system induced by alpha1-adrenoceptors and similar to that in mature brown adipocytes.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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