Combinatorial Effect of Silicon and Calcium Release from Starch-Based Scaffolds on Osteogenic Differentiation of Human Adipose Stem Cells.
Rodrigues AI., Oliveira MB., Mano JF., Gomes ME., Reis RL., Leonor IB.
Laboratory Study, published in ACS Biomater Sci Eng (2015) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- ACS Biomater Sci Eng (2015)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 33445253
- DOI
- 10.1021/acsbiomaterials.5b00113
- Citations
- 5
Abstract (original English)
Instructive materials able to drive cells, in particular the differentiation of stem cells toward osteoblastic lineages, have been investigated as a promising strategy for bone tissue engineering. Inorganic ions, such as phosphorus, calcium, silicon, and strontium, have been used in bone regeneration strategies as instructive ions for material-based approaches. The use of effective inorganic ions is being investigated as a promising approach for bone regeneration applications, mainly because they are highly available and cost-effective and thus reducing the need to use expensive and less-stable growth factors. The aim of the present study is to investigate the effect of the release of silicon (Si) and calcium (Ca) ions from a blend of starch and poly caprolactone (SPCL) scaffolds on the osteogenic behavior of human adipose stem cells (hASCs). The scaffolds were developed by a wet-spinning technique and two different solutions were used as coagulation bath, one containing Ca and Si ions and other one containing only Si ions. The composition of the scaffolds as well as their mechanical properties was also evaluated. Our study showed that both scaffolds were able to sustain cell attachment and induce their differentiation into the osteogenic lineage in basal medium, i.e., in the absence of osteogenic factors. The scaffolds containing both ions, Si and Ca, had a stronger influence
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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