Combined arthroscopic rotator cuff repair with mesenchymal stem cell augmentation shows similar functional outcomes but a higher structural integrity rate compared with isolated repair: a meta-analysis of comparative stu

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Arthroscopic rotator cuff repair (RCR) has guaranteed satisfactory outcomes but remains associated with a significant rate of tendon-bone healing failure. Mesenchymal stem cells (MSCs) have been tested as a promising cell-based therapy for rotator cuff tear (RCT). MSC augmentation has been proposed as a therapy associated with surgical repair, potentially enhancing the overall surgical outcomes for patients with RCTs. The aim of this meta-analysis was to compare functional and structural outcomes between arthroscopic RCR combined with MSC augmentation vs. isolated RCR for RCT. Methods The PubMed, MEDLINE, Scopus, and Cochrane Central databases were used to search keywords, and 5 studies were included. The first author, journal name, year of publication, study design, patient demographics, type of surgery, and follow-up period were recorded. The data extracted for quantitative analysis included the visual analog scale, University of California at Los Angeles score, flexion, external rotation, and retear. Random and fixed effect models were used for the meta-analysis of pooled mean differences and odds ratios. Results A total of 415 patients were identified, 203 of whom underwent combined RCR and MSC augmentation, and 212 underwent isolated RCR. The mean ages were 62.2 ± 6.2 and 61.6 ± 5.7 years in the combined RCR and MSC injection and isolated RCR groups, respectivel

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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