Combined and Layered Fat Injection for Lower Eyelid Wrinkles: Comparative Efficacy in Mild and Severe Cases.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Lower eyelid wrinkles pose a persistent challenge in facial rejuvenation. Layered autologous fat grafting using Coleman fat, SVF-gel, and nanofat offers a regenerative approach with potential synergistic benefits. Objective To assess the efficacy and safety of this layered technique in patients with mild and severe lower eyelid wrinkles. Methods Sixty patients presenting with lower eyelid wrinkles were divided into mild and severe groups according to baseline wrinkle severity. All patients received layered injections of Coleman fat, SVF-gel, and nanofat. Outcomes were evaluated using standardized wrinkle scores, patient satisfaction ratings, and VISIA imaging system analysis, both preoperatively and at 12 months postoperatively. Results Significant improvements in wrinkle scores, VISIA analysis results, and patient satisfaction were observed in both groups at 12 months. Greater wrinkle reduction and satisfaction were achieved in the mild group compared to the severe group. No serious complications were reported. Conclusions Layered injection of Coleman fat, SVF-gel, and nanofat is a safe and effective therapeutic approach for lower eyelid wrinkles. It offers superior and more predictable rejuvenation, particularly for patients with mild wrinkles, supporting its role as an advanced option for lower eyelid wrinkle treatment. Level of evidence iii Therapeutic study. Thi

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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