Combined Use of Botulinum Toxin A and Profhilo for Upper Face Rejuvenation: A Randomized Clinical Trial

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Hyaluronic acid (HA) and Botulinum toxin A (BTX-A) treatments are highly regarded for their effectiveness in facial rejuvenation. Aim To investigate whether adding Profhilo enhances the effects of BTX-A for frontal skin rejuvenation. Method In a prospective clinical trial, 10 subjects were treated by upper face Profhilo plus Botulinum toxin A injection, and 10 age- and sex-matched controls received only Botulinum toxin A injection. Clinical and sonographic improvement were compared 3 months after the last treatment session. Results A total of 20 participants (10 patients in each group), including 8 males (80%) and 2 females (20%) in the case group and 7 males (70%) and 3 females (30%) in the control group, were enrolled in the study. According to Merz scores before and 3 months after treatment, the wrinkles were dramatically reduced in both groups ( p value: p value: 0.633). None of the sonographic variables, including dermis and hypodermis thickness and elasticity, significantly changed after treatment with BTX-A alone ( p values: 0.910 and 0.770, respectively) or with Profhilo injection ( p values: 0.261 and 0.670, respectively). Conclusion We have shown that adding Profhilo to BTX-A injection does not have any short-term clinical or sonographic advantage in frontal area wrinkle reduction. Further prospective studies with a longer follow-up period are warranted to

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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