Comparative Anatomy of Polydactyly and the Adult Nail Unit and Its Implications in the Onychofibroblasts/Onychodermis Theory.
Perrin C.
Laboratory Study, published in Am J Dermatopathol (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Am J Dermatopathol (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41378808
- DOI
- 10.1097/DAD.0000000000002924
Abstract (original English)
Recent studies have proposed the use of the polydactyly nail unit model as a tool for the study of the molecular basis of onychogenesis. However, the histological and immunohistochemical description of this model is still a matter of debate in the literature, and the validity of the concept of the onychodermis used in the histological interpretation of both polydactyly and the adult nail unit has been challenged on the basis of detailed histological studies of adult fingernail units. The aim of this study was to provide new histological and immunohistochemical data on both the adult toenail unit and polydactyly nail unit to test the onychodermis/onychofibroblasts hypothesis. A histological study was performed on a series of 20 normal adult toenails from 10 cadavers and 10 polydactyly nail units. This study supported a strong analogy between the finger and toe dermis of the adult nail. The telocyte population is relatively sparse compared with the fibroblast (fibrocyte) population of the nail mesenchyme as a whole. The dynamic immunohistochemical profile of the nail telocytes was present in both fingers and toes, with the CD34+/CD10+ profile correlating with the onychogenic epithelial region, and the CD34-/CD10+ profile correlating with the spatial rearrangement of the epidermal ridges of the nail bed that are aligned longitudinally and almost parallel to each other. The main di
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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