Comparative Efficacy of Stromal Vascular Fraction and Adipose-derived Stem Cells in UVB-induced Skin Damage in Nude Mice.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Chronic UVB exposure accelerates skin aging by inducing oxidative stress and inflammation, leading to dehydration, reduced collagen density, and impaired epidermal and dermal integrity. Stem cell-based therapies, including the use of the stromal vascular fraction (SVF) and adipose-derived stem cells (ASCs), have emerged as promising approaches for skin regeneration. Objectives This study evaluated the therapeutic effects of SVF and ASCs on UVB-induced skin damage. Methods The mice were exposed to UVB irradiation (290-310 nm) for eight weeks to establish a photoaging model. Following UVB exposure, the SVF or ASCs were injected into the dorsal skin, and the skin samples were analyzed. Results UVB exposure significantly reduced skin hydration (-26%), decreased collagen density, and led to a decrease in the thickness of the epidermal and dermal layers. The SVF and ASC treatments improved skin hydration, enhanced extracellular matrix remodeling, and increased collagen density. Both treatments reduced oxidative stress by decreasing reactive oxygen species (ROS) levels, with SVF-treated samples exhibiting increased BMAL1 expression. SVF and ASCs also promoted angiogenesis and lymphangiogenesis. A reduction in macrophage infiltration and a shift in polarization from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype were also observed in the SVF and ASC g

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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