Comparative study of bladder augmentation using different biomimetic scaffolds: electrospun nanofiber vs. extracellular matrix scaffold with adipose-derived stem cells.
Wang X., Zhang F., Zhou Z., Fu Q., Liao L.
Animal Study, published in Int J Surg (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Int J Surg (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 40788005
- PMCID
- PMC12695190
- DOI
- 10.1097/JS9.0000000000003152
- Citations
- 3
Abstract (original English)
Background Bladder augmentation with gastrointestinal segments is a widely used surgical procedure for neurogenic bladder, but it carries a risk of many side effects. However, there have been no systematic studies on which biomaterials are suitable for bladder augmentation and reconstruction. The aim of this study was to compare the safety and applicability of small intestinal submucosa (SIS), poly(l-lactic) acid (PLLA) nanofibrous scaffold, and PLLA/gelatin composite nanofibrous scaffold as a potential bladder wall substitute material in tissue-engineered bladder augmentation and reconstruction. The results provide a scientific basis for selecting appropriate materials in clinical applications. Materials and methods The microstructure, cytocompatibility, cell adhesion, and histocompatibility of scaffolds including SIS, PLLA nanofiber scaffold, and PLLA/Gelatin were observed. Furthermore, bladder augmentation rabbit models were constructed using scaffolds with and without adipose-derived stem cells (ASCs) implantation. Cystography and urodynamic examination were performed to evaluate the morphology and function of the reconstructed bladder. Histologic and immunofluorescence were used to assess the regeneration status of the reconstructed bladder. Results Compared to SIS and PLLA/Gelatin scaffolds, the PLLA scaffold possessed appropriate mechanical properties, pore size and poro
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.