Comparing the potential efficacy of stromal vascular fraction and adipose mesenchymal stem cell-derived exosomes in a rat model of chromium-induced thyroid dysfunction.

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Occupational exposure to toxic heavy metals may render industrial workers susceptible to thyroid-related problems. Chromium (Cr) in its hexavalent form is highly toxic and a known carcinogen. This research is the first experimental study to investigate the possible protective role of adipose mesenchymal stem cell (MSC)-derived exosomes (ADMSCs-E) versus stromal vascular fraction (SVF) exosomes in a rat model of Cr-induced thyrotoxicity, using behavioral, histological, immunohistochemical, and biochemical studies, with correlation assessed using morphometric and statistical methods. Methods Forty-two male rats were randomly assigned to a donor group (n = 10) for preparation of ADMSCs-E and SVF and four experimental groups (n = 8 each): control, Chromium-treated (60 μg/kg I.P), Exosomes-treated, and SVF-treated groups. Behavioral changes were assessed through the open field and elevated plus maze (EPM) tests. Blood samples were collected to measure T3, T4, TSH, tumor necrosis factor-alpha (TNF-α), and malondialdehyde (MDA) in serum. Thyroid tissues were then subjected to histological, immunohistochemical, ultrastructural, and morphometric analyses. Additionally, Pax3 mRNA expression was evaluated using qRT-PCR. Results Following exposure to potassium dichromate, the thyroid histological and ultrastructural architecture was significantly disrupted, leading to altered th

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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