Comparison of administration methods in adipose tissue-derived stem cell therapy in rats with colitis: An experimental study.
Safak A., Erkent M., Ozgun G., Ozer HEO., Tezcaner T., Karakaya E.
Laboratory Study, published in North Clin Istanb (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- North Clin Istanb (2025)
- Country
- Turkey
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41573061
- PMCID
- PMC12821132
- DOI
- 10.14744/nci.2025.45649
Abstract (original English)
Stem cell studies have been increasing in recent years owing to the healing effect of stem cells on colitis. This study aimed to compare the effects of locally and intra-arterially administered adipose tissue-derived stem cells (ATDSCs) in a colitis model induced by acetic acid (AA). Five groups were established, each consisting of six Wistar-Albino male rats. Group 1, colitis control group; Group 2, local phosphate-buffered saline (PBS) group; Group 3, local stem cell group; Group 4, intra-arterial PBS group; Group 5, intra-arterial stem cell group. Colitis was induced by the rectal administration of acetic acid. All rats were weighed on the day colitis was induced, on the day of stem cell administration (day 7), and on the day of sacrifice (day 14). All groups were evaluated for weight loss, histopathology, blood tumor necrosis factor-α-stimulated gene/protein-6 (TSG-6) levels, macroscopic laparotomy findings, and fluorescence microscopy. Significant weight loss was observed in all the animals with colitis (p<0.05). Histopathological examination revealed less mucosal damage and greater healing in the intra-arterial group (p<0.05). Blood TSG-6 levels were also significantly higher in the intra-arterial group than in the other groups (p<0.05). Immunofluorescence microscopy showed that intra-arterially administered stem cells exhibited a more uniform and widespread distribution
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
How we grade evidenceBrowse all related research
Filter the research library by this study's title keywords, author, or publication year.