Comparison of the Effects of Adipose Extracellular Matrix/Stromal Vascular Fraction Gel Injection and CO 2 Fractional Laser on Atrophic Acne Scar in Asians Through a 24-Week Prospective, Randomized, Split-Face Study.

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Adipose extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) contains adipose-derived stem cells, extracellular matrix, and other cell components, and possesses the ability to promote collagen production and serve as a filling agent. To assess the efficacy and safety of ECM/SVF-gel injection for the treatment of acne scars, compared to CO 2 fractional laser (CO 2 FL). We performed an open-label, investigator-initiated, assessor-blinded, split-face trial in Xijing Hospital, China, between July 11, 2020, and December 30, 2022. Patients exhibiting moderate to severe acne scars were randomly assigned to a single ECM/SVF-gel injection on one half of the face or two sessions of CO 2 FL treatments on the other half. The primary outcome was the change in total Echelle d'Evaluation Clinique des Cicatrices d'acne (ECCA) score from baseline to 24-week follow-up. Secondary outcomes included the changes in the volume of scars assessed by the Antera 3D software. A total of 11 participants were enrolled, and 10 completed the follow-up. The mean age of patients was 27.5 ± 4.2, 7 female and four male, seven with Fitzpatrick skin Type III and four with Type IV. At 24weeks, the mean change in ECCA score was -60.25 on the side of ECM/SVF-gel injection and - 43.25 on the side of CO 2 FL treatment (difference:-17.00 [95% CI: -24.56 to -9.44], p < 0.001). Antera 3D photography analysis sh

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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