Comparison of the Fitting Validity Between the 2P Model and the Nondilute Solution Model Using Statistical Methods in Modeling Cell Membrane Permeabilities.
Zhang Y., Zhao G., Yi J., Shu Z., Zhou P., Cao Y.
Laboratory Study, published in Biopreserv Biobank (2015) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Laboratory Study
- Journal
- Biopreserv Biobank (2015)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 26691959
- DOI
- 10.1089/bio.2015.0047
- Citations
- 1
Abstract (original English)
In cryopreservation, the two-parameter (2P) model and the nondilute solution model have been developed to study the membrane transport properties of cells. However, to our knowledge, comparison of the fitting validity has never been made between the two models. In this study, to make this comparison, the permeability parameters of porcine adipose-derived stem cells (pADSCs) were first determined with the two models, and then the errors between the predictions and the experimental data were tested using the Lilliefors test. The results indicate that the 2P model is slightly better than the nondilute solution model in predicting the mass transport across cell membrane. The causes for this phenomenon are discussed and suggestions on using these two models are given.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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