Comparison of Periodontal Ligament Stem Cells with Mesenchymal Stem Cells from Other Sources: A Scoping Systematic Review of In vitro and In vivo Studies.
Kadkhoda Z., Motie P., Rad MR., Mohaghegh S., Kouhestani F., Motamedian SR.
Systematic Review on Ligament Injury, Immune Modulation, published in Curr Stem Cell Res Ther (2024) — summary generated from the PubMed abstract.
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Systematic Review
- Journal
- Curr Stem Cell Res Ther (2024)
- Country
- United Arab Emirates
- Reported sample size
- —
- PMID
- 36397622
- DOI
- 10.2174/1574888X17666220429123319
Abstract (original English)
The application of stem cells in regenerative medicine depends on their biological properties. This scoping review aimed to compare the features of periodontal ligament stem cells (PDLSSCs) with stem cells derived from other sources. An electronic search in PubMed/Medline, Embase, Scopus, Google Scholar and Science Direct was conducted to identify in vitro and in vivo studies limited to English language. Overall, 65 articles were included. Most comparisons were made between bone marrow stem cells (BMSCs) and PDLSCs. BMSCs were found to have lower proliferation and higher osteogenesis potential in vitro and in vivo than PDLSCs; on the contrary, dental follicle stem cells and umbilical cord mesenchymal stem cells (UCMSCs) had a higher proliferative ability and lower osteogenesis than PDLSCs. Moreover, UCMSCs exhibited a higher apoptotic rate, hTERT expression, and relative telomerase length. The immunomodulatory function of adipose-derived stem cells and BMSCs was comparable to PDLSCs. Gingival mesenchymal stem cells showed less sensitivity to long-term culture. Both pure and mixed gingival cells had lower osteogenic ability compared to PDLSCs. Comparison of dental pulp stem cells (DPSCs) with PDLSCs regarding proliferation rate, osteo/adipogenesis, and immunomodulatory properties was contradictory; however, in vivo bone formation of DPSCs seemed to be lower than PDLSCs. In light
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.
How we grade evidenceRelated research
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Systematic Review with a reported sample of 29 on Ligament Injury, Immune Modulation, published in BMC Oral Health (2025) — summary generated from the PubMed abstract.
- 2025
- n = 29
BMC Oral Health - Level ASystematic Review
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J Appl Biomater Funct Mater - Level ASystematic Review
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Systematic Review on Ligament Injury, published in Tissue Eng Part B Rev (2022) — summary generated from the PubMed abstract.
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Tissue Eng Part B Rev - Level ASystematic Review
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Systematic Review on Ligament Injury, published in Arthroscopy (2022) — summary generated from the PubMed abstract.
- 2022
Arthroscopy