Compatibility of Hepatocyte Growth Factor, Adipose-Derived Mesenchymal Stem Cells, and Dermal Fillers for the Treatment of Vocal Fold Scar.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Vocal fold (VF) scar and sulcus cause severe vocal problems, however optimal treatment methods are not well established. We tested the viability of mesenchymal stem cell (MSC) therapy in combination with hepatocyte growth factor (HGF) in a hyaluronic acid-based (HA) hydrogel. There was a significant increase in the metabolic output of adipose- derived mesenchymal stem cells (AD-MSC) grown in the presence of HGF up to 1 ug/mL when compared to control wells. Metabolic activity of AD-MSC in the presence of 2 ug/mL HGF was similar to controls. No significant differences were detected between any of the groups when compared to control wells. The results from these experiments provide evidence for the compatibility of the tested products; recombinant human HGF, human AD-MSC, and HA-based dermal fillers. These pre-clinical results support the ongoing research of this combination therapy in treating VF scar.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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