A Concise Review of the Impact of Photobiomodulation (PBM) on Neuronal Differentiation in Adipose-Derived Mesenchymal Stem Cells.
Mobini N., Shirkavand A., Farivar S.
Narrative Review, published in J Lasers Med Sci (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- J Lasers Med Sci (2026)
- Country
- Iran
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 42233114
- PMCID
- PMC13224325
- DOI
- 10.34172/jlms.2026.01
Abstract (original English)
Introduction: Photobiomodulation (PBM), utilizing low-level light, has shown significant potential in differentiating adipose-derived mesenchymal stem cells (ADMSCs) into neuronal cells. Critical studies have shown that specific laser parameters, such as wavelength and fluence, significantly impact the trans-differentiation outcomes of immortalized ADMSCs. This review aimed to consider this phenomenon. Methods: This review was conducted based on several English articles from Google Scholar, Science Direct, and Medline, such as the National Library of Medicine (NLM) and PubMed from 2010 to 2025. The term 'ADMSCs' was searched combined with the following keywords: "Photobiomodulation" OR "low-level laser irradiation" OR "low-power" laser OR "low-intensity laser" OR "Photobiostimulation". Results: This investigation demonstrated that PBM is a non-invasive, light-based method for facilitating the neuronal differentiation of the ADMSCs. It is effective for increased production of adenosine triphosphate (ATP) and other biomolecules responsible for cell differentiation, proliferation, and migration to induce cell proliferation and cell signaling cascades, favoring neuronal lineage commitment, although results vary across protocols. Conclusion: This review indicates that PBMT-based regenerative medicine seems promising and applicable for future advances in cell-based regenerative medic
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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