Conditioned media from adipose-derived mesenchymal stem cells improves movento induced lung damage in male rats.
Zangiabadi I., Rajizadeh MA., Askaripour M., Bagheri MM., Jafari E., Rajabi S.
Animal Study, published in BMC Pulm Med (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- BMC Pulm Med (2025)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41063103
- PMCID
- PMC12505815
- DOI
- 10.1186/s12890-025-03940-2
Abstract (original English)
Insecticides are chemicals agents used to kill insects to increase crop growth. But they can be toxic to humans and wildlife. Movento is an insecticide which is highly toxic to humans and animals by oral, dermal, and inhalation routes. This research is to assess the pulmonary impacts of this insecticide, which have not been explored in previous research. Wistar rats were adopted to four groups. 1- Control (CTL), 2- Movento (M), 3- M in conjunction with Basal medium (BM), 4- M in conjunction with Conditioned medium (CM). For evaluation of the degree of injury and fibrosis, the Hematoxylin and Eosin (H&E) and Masson's trichrome stainings were done respectively. Oxidative stress markers and inflammatory mediators were analyzed utilizing appropriate assays. In rats administered Movento's insecticide, antioxidant markers diminished in comparison to the control group; however, curation with CM markedly elevated them relative to the M and M + BM groups. Movento elevated histological score, fibrosis, MDA, TNF-α, and IL-6 compared to the control group, whereas CM remarkably diminished these parameters in relation to the M and M + BM groups. Conditioned media derived from mesenchymal stem cells (CM-MSC) may function as a therapeutic intervention for lung illnesses induced by movento in rat lungs. It may also serve as a potential treatment of alleviating lung injuries in farmers who are e
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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