Consideration of bone regeneration effect of stem cells: comparison of bone regeneration between bone marrow stem cells and adipose-derived stem cells.
Han DS., Chang HK., Kim KR., Woo SM.
Animal Study, published in J Craniofac Surg (2014) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- J Craniofac Surg (2014)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 24406577
- DOI
- 10.1097/SCS.0000000000000378
- Citations
- 17
Abstract (original English)
Background Much controversy exists as to how stem cells efficiently differentiate and regenerate. To research how stem cell origin affects optimal differentiation and regeneration, the authors collected stem cells from bone marrow and fat and compared amounts of bone regeneration from both groups of cells. Methods This study used 16 New Zealand white rabbits raised in similar surroundings and conditions. After collecting stem cells from bone marrow and fat, osteoblast generation was induced. In each rabbit, 2 craniectomies (10 × 10 mm) were made into each rabbit's calvarium, and 0.2 mL (1 × 10(6) cells/mL) of bone marrow-derived and adipose-derived stem cells were transplanted into each defect. After 3 and 5 weeks of transplantation, computed tomography was conducted. After 6 weeks, regenerated bone tissue was collected and measured for volume, and biopsy was performed. Results Both bone marrow- and adipose-derived stem cells were effective in bone regeneration of the defect. Bone marrow stem cells demonstrated greater differentiation into osteoblasts, but there was no difference in the amount of measured regenerated bone volume after 6 weeks. Conclusions Adipose-derived stem cells differentiate directly into osteoblasts less often than do bone marrow-derived stem cells. However, the total amount of regenerated bone is almost the same because of the effect of indirect bone rege
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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