Constitutive and regulated marrow adipocytes do not actively inhibit B lymphopoiesis.
Montecino-Rodriguez E., Baker E., Dorshkind K.
Animal Study, published in J Immunol (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- J Immunol (2026)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41764735
- DOI
- 10.1093/jimmun/vkag006
Abstract (original English)
Adipocytes accumulate in the bone marrow with age. This has been proposed to trigger age-related changes in hematopoiesis that include a decline in B cell development. Bone marrow fat cells differ from adipocytes in other areas of the body and include 2 subsets termed constitutive and regulated adipocytes. These 2 types of marrow adipocytes have distinct properties and distribution across the skeleton. We assessed the contribution of each adipocyte subset to the loss of B cell progenitors and the age-related increase in hematopoietic stem cells (HSCs) and myeloid progenitors by quantifying their frequency and number in constitutive and regulated adipocyte containing bones from young and old animals. We also examined hematopoiesis in mice fed a high fat diet, which increases marrow adipose tissue, and quantified the expression of genes encoding inflammatory cytokines in constitutive and regulated adipocytes from young and old mice. The results indicated that marrow adipocytes do not actively drive the decline of B lymphopoiesis and other changes in hematopoiesis that occur with age. Instead, the findings support a model in which the age-related expansion of constitutive and regulated fat decreases marrow space available for blood cell production thereby reducing the number of cells from all lineages and stages of hematopoietic development.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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