Constructing the Well Regenerated Decellularized Adipose Tissue Using External Volume Expansion Device.
Long J., Xue P., Zhang Y., Chen G., Qin Z., Zhou X.
Animal Study, published in Aesthetic Plast Surg (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Aesthetic Plast Surg (2025)
- Country
- United States
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 39806137
- DOI
- 10.1007/s00266-024-04604-y
Abstract (original English)
Background External volume expansion (EVE) devices has been demonstrated to enhance the survival of fat grafts. Decellularized adipose tissue (DAT) serves as a promising scaffold for adipose regeneration; however, the effectiveness of adipose regeneration in DAT remains limited, and the underlying mechanisms of its regeneration require further investigation. Objective This study explores the potential of EVE technology to enhance DAT-mediated adipogenesis by facilitating cellular recruitment and establishing a microenvironment conducive to adipose tissue regeneration. Methods DAT was injected into the dorsal area of rats, followed by daily treatment with an EVE suction device for 10 hours per day over 14 days. Control groups underwent transplantation without suction. After the treatment period, tissue samples were collected and analyzed. This included volume measurement, H&E staining, immunofluorescence staining for CD34, CD90, CD68, CD31, and perilipin, electron microscopy for microscopic analysis, and ELISA analysis for IL1, TNFα, CCL2, and CXCL12. Results Fourteen days post-transplantation, the volume of DAT significantly increased in the EVE group compared to the control group. Histological H&E staining revealed a higher peripheral region in the EVE group. Electron microscopy examination showed that EVE suction led to increased porosity in the DAT material, with a greater n
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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