Construction of a Subcutaneous Fat Transplantation Model Infected with Mycobacterium.
Diao W., Hu Y., Chen X., Li W., Kpegah JKSK., Chen X.
Animal Study, published in Curr Med Chem (2026) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Animal Study
- Journal
- Curr Med Chem (2026)
- Country
- United Arab Emirates
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 39917930
- DOI
- 10.2174/0109298673345671250114235930
Abstract (original English)
Introduction Fat grafting procedures for body contouring and cosmetic reconstruction have received widespread attention. Methods In recent years, there has been an increase in post-fat grafting infections caused by Mycobacterium abscessus (MA) , and there is a lack of representative and standardized murine models of infection; therefore, there has been limited research on the treatment of post-fat grafting MA infections. To overcome this challenge, we constructed an MA infection model after fat grafting. Results By evaluating skin charge, dermatopathology, and inflammatory markers, we found that the fat graft + 1×10 9 CFU/mL bacterial suspension infection group had significant inflammatory symptoms and elevated inflammatory factors on postoperative day 10. Conclusion The model construction process was simple and reproducible, which paves the way for further studies on the impact of MA pathogenesis and the efficacy of new treatments.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is preclinical work; animal or laboratory results cannot be applied to humans.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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