Contemporary Management Strategies for Peyronie's Disease: A Comprehensive Review

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Peyronie's disease (PD) is an acquired fibrotic condition of the tunica albuginea that is characterized by penile curvature, deformity, pain, and impaired sexual function. PD is prevalent among all ages and is responsible for significant psychological distress. This review summarizes the current knowledge on PD, covering its epidemiology, risk factors, and natural history, along with a comprehensive overview of the medical, intralesional, and surgical options. While the traditional treatments are well-described in previous publications, the focus of the current review is on new biologic and regenerative treatments. Increasing attention to therapies such as platelet-rich plasma and stem cells is representative of the larger trend toward attempts at modifying the underlying fibrotic process, as opposed to merely correcting deformity. By integrating evolving regenerative strategies with proven therapeutic options and prioritizing patient-centered counselling, future PD care may become increasingly individualized, effective, and less invasive.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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