Corpus cavernosum and tunica albuginea reconstruction by tissue engineering: towards functional erectile structures regeneration
Guo Y., Ma N., Li Y., Yang Z., Chen S., Liu P.
Narrative Review, published in BMC Urol (2024) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- BMC Urol (2024)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 39716143
- PMCID
- PMC11665024
- DOI
- 10.1186/s12894-024-01605-6
Abstract (original English)
Background Current treatments for penile erectile structures reconstruction are limited and remain a great challenge in clinical practice. Tissue engineering techniques using different seed cells and scaffolds to construct a neo-tissue open promising avenues for penile erectile structures repair and replacement and show great promise in the restoration of: structure, mechanical property, and function which matches the original tissue. Methods A comprehensive literature review was conducted by accessing the NCBI PubMed, Cochrane, and Google Scholar databases from January 1, 1990, to January, 1, 2022 using the search terms "Tissue engineering, Corpus cavernosum (CC), Tunica albuginea (TA), Acellular Matrix, Penile Reconstruction". Articles were screened and assessed by two independent reviewers to determine whether those met the inclusion criteria, and a total of 19 articles were being selected and included in the data analysis. Results Tissue engineered cell-seeded scaffold can reconstruct a similar structure to native TA and CC and showed good histocompatibility with no immunological rejection. The results of the evaluation of morphological feature, intracavernosal pressure, and erectile-related nitric oxide (NO) expression were strongly proofs that the tissue engineered graft can significantly improve the penile erectile and ejaculatory function. In addition, increasing the pu
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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