Correlation Analysis of Serum G-Protein-Coupled Receptor 4 and Biglycan Levels with the Severity of Intervertebral Disc Degeneration

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Objective To investigate the correlation between serum levels of G protein-coupled receptor 4 (GPR4) and Biglycan (BGN) with the severity of Intervertebral Disc Degeneration (IVDD). Methods A total of 162 patients with IVDD treated at our hospital from August 2023 to August 2024 were included. The general information of patients was retrospectively collected. MRI was used to assess IVDD severity using the Pfirrmann grading system. Serum GPR4 and BGN levels were measured by enzyme-linked immunosorbent assay (ELISA). Multiple linear regression analysis was performed to identify risk factors for IVDD severity. Spearman 's and Pearson 's correlation analyses were used to evaluate the relationships between serum GPR4, BGN, and IVDD severity. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic value of serum GPR4 and BGN in IVDD. Results Significant differences in age and the proportion of diabetic patients as well as serum GPR4 and BGN were found among different Pfirrmann grades ( P P P r =0.651, r =0.488, P r =-0.591, P Spearman correlation analysis showed a negative correlation between serum GPR4 and BGN ( P P Conclusions Serum GPR4 and BGN levels are identified as effective diagnostic indicators for IVDD, with serum GPR4 positively correlated but BGN negatively correlated with the severity of IVDD.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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