The critical role of necroptosis in oil cyst formation associated with autologous fat transplantation.
Chen RX., Du HY., Zhu XR., Zhao C., Zhang JX., Jiang SX.
Prospective Study, published in Cell Commun Signal (2026) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Prospective Study
- Journal
- Cell Commun Signal (2026)
- Country
- England
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41857749
- PMCID
- PMC13123006
- DOI
- 10.1186/s12964-026-02821-3
Abstract (original English)
BACKGROUND: Autologous fat transplantation (AFT) is widely used in aesthetic and reconstructive surgery, but its long-term outcomes remain unpredictable because of complications such as oil cyst formation, the underlying mechanisms of which are poorly understood. This study aimed to investigate the pathogenesis of oil cyst development in grafted fat and explore potential pharmacological interventions. METHODS: We established a refined and reproducible mouse model of fat grafting to simulate post transplantation oil cyst formation. Molecular signaling pathways were analyzed using immunohistochemistry and western blotting. The role of necroptosis was further evaluated through genetic and pharmacological approaches. Clinical human samples of oil cysts obtained from patients who underwent AFT were also examined to validate the findings in the mouse model. Finally, the effects of metformin, an FDA-approved drug, on necroptosis and oil cyst formation were evaluated in the experimental model. RESULTS: Our results demonstrated that necroptosis, predominantly in adipocytes, is closely associated with oil cyst formation. Activation of the RIPK3–MLKL signaling axis was identified as the key molecular mechanism promoting necroptosis in grafted fat. These findings were corroborated in human oil cyst samples, in which the same pathway was activated. Treatment with metformin significantly inh
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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