The crucial role of circadian synchronization in bone marrow adipose tissue mesenchymal stem cells: insights into pathogenesis in Fanconi anemia and acute myeloid leukemia.
Muratoğlu B., Özdemir C., Eylem CC., Reçber T., Nemutlu E., Uçkan-Çetinkaya D.
Cohort Study, published in Mol Biol Rep (2025) — summary generated from the PubMed abstract.
Early human evidence such as case series or small samples is exploring possible benefits.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Cohort Study
- Journal
- Mol Biol Rep (2025)
- Country
- Netherlands
- Reported sample size
- —
- Source database
- PubMed
- PMID
- 41236654
- DOI
- 10.1007/s11033-025-11229-0
Abstract (original English)
The circadian rhythms, intrinsic 24-hour oscillations in physiological and cellular processes, serve as fundamental regulators of cellular function and metabolism. Although these rhythms are robust, they are susceptible to dysregulation, particularly in hematological diseases, where circadian misalignment exacerbates pathological conditions. The role of bone marrow adipose tissue mesenchymal stem cells (BMAT-MSCs), a dynamic component of the bone marrow microenvironment, in the pathogenesis of Fanconi anemia (FA), a genetic disorder characterized by a predisposition to myeloproliferative disease and acute myeloid leukemia (AML), remains poorly understood. This study explores the potential therapeutic applications of dexamethasone (DEX)-induced synchronization in BMAT-MSCs derived from healthy donors (HD), FA, and AML. BMAT-MSCs were subjected to DEX-induced synchronization to emulate in vivo conditions, after which comprehensive analyses of circadian gene expression, metabolomic and lipidomic profiles were conducted. Synchronization restored PER1 rhythmicity across all groups, indicating effective circadian entrainment, whereas CRY1 rhythms were attenuated in FA and AML. Lipidomic and metabolomic readouts under synchronized conditions showed more consistent, timepoint-aligned patterns than in unsynchronized cells, enabling clearer identification of group-specific alterations, i
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
Evidence level
Early human evidence such as case series or small samples is exploring possible benefits.
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