Cyclodextrins as multifunctional tools for advanced biomaterials in tissue repair and regeneration
Lee YB., Kyun ML., Lee YJ., Shim HE., Huh KM., Kang SW.
Narrative Review, published in Bioact Mater (2025) — summary generated from the PubMed abstract.
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
- Level A · Stronger Clinical Evidence
- Level B · Emerging clinical evidence with positive signals
- Level C · Early human research exploring benefits
- Level D · Scientific groundwork from lab and animal studies
- Emerging · Emerging topic under active research
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Bioact Mater (2025)
- Reported sample size
- —
- Source database
- Europe PMC
- PMID
- 40212783
- PMCID
- PMC11985092
- DOI
- 10.1016/j.bioactmat.2025.03.018
- Citations
- 7
Abstract (original English)
Cyclodextrins (CDs), characterized by their unique cyclic oligosaccharide structure and exceptional capacity for molecular encapsulation through host-guest interactions, have garnered significant attention as versatile building blocks in advanced biomaterials. This review explores the application of CD-based biomaterials in tissue engineering and regenerative medicine, emphasizing their synthesis, physicochemical characterization, biocompatibility, and translational potential. Special emphasis is placed on the development of CD-modified hydrogels, their interaction with host-guest molecules, and their use in advanced therapeutic strategies. Additionally, we discuss various fabrication methods for CD-based biomaterials, including physical and covalent crosslinking, self-assembly, and enzymatic crosslinking, each providing unique properties suited for advanced therapeutic strategies. Safety considerations and potential regulatory challenges associated with these materials are also examined. By providing a comprehensive overview of recent advancements, this review aims to highlight the promising role of cyclodextrins as multifunctional tools in enhancing tissue repair and regeneration, paving the way for innovative therapeutic solutions in clinical settings.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.
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