Decellularized Adipose Matrix Rejuvenates Photoaged Skin through Immune Microenvironment Modulation

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Objective: This study aims to explore the therapeutic potential of decellularized adipose matrix (DAM) in rejuvenating photoaged skin by modulating the immune microenvironment. Impact Statement: DAM effectively induces M1 to M2 macrophage polarization and rescues the function of photoaged fibroblasts through paracrine mechanisms, providing a novel strategy for skin antiaging through immune microenvironment remodeling. Introduction: Photoaging, triggered by prolonged ultraviolet exposure, is marked by the depletion of skin structural elements and a persistent inflammatory environment. Current clinical interventions primarily target structural defects, while immune modulation remains underexplored. Therefore, developing biomaterials with both extracellular matrix (ECM) replenishment and immune regulatory functions is crucial for skin regeneration. Methods: A photoaged mouse model was established using ultraviolet B irradiation to validate the inflammatory microenvironment. DAM was prepared via physicochemical decellularization and assessed in vitro for its effects on macrophage polarization and macrophage-fibroblast cross-talk. A DAM-functionalized hyaluronic acid (HA/DAM) hydrogel was developed and evaluated for its effects on skin rejuvenation via subcutaneous injection. Results: In vitro experiments demonstrated that DAM substantially promoted M2 macrophage polarization, and M

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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