Decoding the significance of TERT gene in Polycystic Ovary Syndrome: From molecular mechanisms to emerging diagnostic and therapeutic strategies

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Polycystic Ovary Syndrome (PCOS) is a complex endocrine condition affecting women of reproductive age, characterized by hyperandrogenism, anovulation, and polycystic ovary morphology. It is influenced by environmental and genetic factors with high heritability and is associated with metabolic issues such as insulin resistance (IR), chronic inflammation, and oxidative stress. Despite extensive research, the molecular mechanism behind PCOS pathophysiology is still not fully understood. Recent studies highlighted the role of telomere biology and telomerase activity (TA), particularly that of telomere reverse transcriptase (TERT), in the development and progression of PCOS. Telomerase, a complex of ribonucleoprotein enzymes, is responsible for maintaining telomere length (TL). TERT promotes telomere stability, and its disturbance has been associated with reproductive diseases such as PCOS. This study critically examines the results of current studies on the TERT gene and its association with PCOS, as well as the mechanism underlying the reduction in TERT gene expression in women with PCOS. The review also highlights the key molecular discoveries related to TERT dysregulation in PCOS and its impact on clinical outcomes, suggesting that TERT expression levels can reflect disease severity, ovarian reserve, and the effectiveness of treatments in PCOS patients. TERT expression may be re

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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